LeOra Software Company ®
We produce computer software for conducting quantal response bioassays using probit or logit regression analyses. We have univariate and multivariate programs for this, and programs to assist in designing tests of various statistical models. All of our programs run on an IBM PC compatible platform with Microsoft Windows 98, ME, XT, 2000, and XP. The following are brief descriptions of the programs. (The first part of each program's name comes from "probit or logit.")
PoloPlus© computes probit (or logit) quantal regression analyses and conducts automatic tests of the hypotheses of parallelism and equality. Several features enhance the program’s use in toxicological and pharmaceutical testing. First, lethal dose ratios are estimated for statistical comparison of each preparation with a standard. Second, standardized residuals are calculated. Third, the residuals are displayed in plots for identification of sources of lack-of-fit to the probit or logit model. Fourth, a fitted response curve for each preparation can be plotted. Finally, a Probit 9 (LD 99.9968) can be estimated to meet the requirements of the United States Department of Agriculture and regulatory agencies of other nations.
PoloEncore© does the work of PoloPlus but extends it to binary response models with multiple explanatory variables. Such models are rather common in bioassays with chemicals such as pesticides and pharmaceuticals. They provide an efficient means to use a single experiment to test the significance of more than one variable (such as dose) on response.
PoloMix© uses a chi-square statistic to test the hypothesis of independent joint action. This test is done by obtaining an estimate for the probability of mortality p for several dose or concentration levels of the two components and then comparing the estimate of p with the observed proportion killed at the corresponding dose levels. The three contributions to p are estimated separately. First, p0 is calculated as the proportional mortality observed in the control group. Next, p1 and p2 are estimated from bioassays of component 1 and component 2, with data analyzed with PoloPlus. Finally, the chi-square test statistic is calculated.
PoloDose© is a program designed specifically for the study of dose placement and sample size for any dose that would cause mortality greater than zero and less then 100%. PoloDose calculates the length of the confidence interval for µ0, the dose level that produces a certain probability of response P0, where 0<P0<1. In this program, P0 is estimated to 30 digits, thus permitting examination of doses necessary to estimate the probit and logit 9. The program is written to assist in the selection of the optimal doses to use in a bioassay that involves binary (e.g., dead vs. alive) response. The results of the bioassay can then be analyzed by PoloPlus.
REFERENCE
These software programs are discussed in the book, Bioassays with Arthropods, Second Edition, by Jacqueline L. Robertson, Robert M. Russell, Haiganoush Preisler, and N. Eugene Savin. (Taylor & Francis CRC Press, 2007) For more information click CRC Press, then choose "Life Science", then "Entomology", then "A-Z by Title", then scroll down to Bioassays with Arthropods.
AVAILABILITY
All four programs are contained on a single CD, along with a complete User’s Guide for each program in electronic form as a PDF file which you can print. (PDF files can be read and printed by Adobe Reader, which you can obtain free from Adobe Systems at www.adobe.com)
PRICE
$250 per CD containing all four programs and their user's guides. Prepayment or a purchase order number is required (U. S. funds) before the programs can be shipped. We now accept PayPal. We do not accept credit cards at this time.
ORDERING
You can order by any one of the following methods:
• Regular mail, by hand: Print the form, fill it out, and mail it with payment to us at the address below.
• Regular mail, by word processor: Copy and paste the form into a word processing program, fill it out, print it, and mail it with payment to us at the address below.
• Fax: Fax the filled-in form, with payment details, to 707-762-1124 begin_of_the_skype_highlighting 707-762-1124 end_of_the_skype_highlighting (USA).
• Email: Email the form information, with payment details, to LeOra Software
• PayPal: Go to www.PayPal.com
Our mailing address is:
LeOra Software Company
1007 B St.,
Petaluma, CA 94952 (USA)
Our Federal Tax ID is 20-0308173.
ORDER FORM
Name Affiliation Address Telephone number E-mail address Number of CDs Total price ($250 per CD)
LeOra Software Company ®